abstract：BACKGROUND:The functional index for hand osteoarthritis (FIHOA), a 10-item investigator-administered questionnaire, was validated in 1995. It is relevant, reliable and has good external and internal validities. OBJECTIVE:To assess the sensitivity to change over time of the FIHOA. PATIENTS/METHODS: PATIENTS:symptomat...

journal_title：Osteoarthritis and cartilage

authors： Dreiser RL,Maheu E,Guillou GB

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:Since complete meniscectomy leads to knee OA, we investigated the potential links among meniscal subluxation, joint space narrowing and symptomatic OA. MATERIALS AND METHODS:233 cases with symptomatic knee OA and 58 asymptomatic controls underwent radiography and MR imaging of the knee. Joint space narrowing...

journal_title：Osteoarthritis and cartilage

authors： Gale DR,Chaisson CE,Totterman SM,Schwartz RK,Gale ME,Felson D

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:Osteoarthritis (OA) is a degenerative joint disease with an incidence exceeding 10% of the adult population. In end stages, OA can result in severe restriction of activity and consequent disability. For these severe cases of OA, no effective remedy is available yet. Joint distraction is a new experimental app...

journal_title：Osteoarthritis and cartilage

authors： van Valburg AA,van Roermund PM,Marijnissen AC,van Melkebeek J,Lammens J,Verbout AJ,Lafeber FP,Bijlsma JW

更新日期：1999-09-01 00:00:00

abstract：:Osteoarthritis (OA) is not caused by a simple consequence of aging and cartilage degradation. Based on the conventional paradigm, OA has been considered a degenerative joint disorder. However, the dominant clinical symptom has been characterized by a non-infectious chronic inflammatory condition with infiltration of i...

journal_title：Osteoarthritis and cartilage

authors： Nakamura H,Yoshino S,Kato T,Tsuruha J,Nishioka K

更新日期：1999-07-01 00:00:00

abstract：:Radiographic sensitivity for quantifying the rate of change in joint space width (JSW) for DMOAD trials, is influenced by the following, which vary between methodologies for imaging hip, knee and hand. Radio-anatomical plane of measurement JSW measurement precision is improve when the (i) joint is in a normal function...

journal_title：Osteoarthritis and cartilage

authors： Buckland-Wright

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:Diacetylrhein or diacerein has shown efficacy in the treatment of both major forms of osteoarthritis (OA), coxarthrosis as well as gonarthrosis, improving clinical symptoms of the disease (pain reduction and algo-functional index). Both in-vitro and animal models studies suggest that diacerein may have also d...

journal_title：Osteoarthritis and cartilage

authors： Felisaz N,Boumediene K,Ghayor C,Herrouin JF,Bogdanowicz P,Galerra P,Pujol JP

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVE:To compare the sensitivity of WOMAC and the two added dimensions Sport and Recreation Function and Knee Related Quality of Life in subjects with radiographic knee OA to that in controls. To study the influence of age on the reported outcomes. DESIGN:Outcomes were compared between subjects having had meniscec...

journal_title：Osteoarthritis and cartilage

authors： Roos EM,Roos HP,Lohmander LS

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:The purpose of this paper is to review changes in the biomechanical properties of tendons and ligaments from joint disuse. METHOD:We have reviewed 37 experimental studies on joint disuse, which have been carried out with various models of disuse and with various animals. RESULTS:Immobilization of joints has...

journal_title：Osteoarthritis and cartilage

authors： Yasuda K,Hayashi K

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:To describe changes to the cancellous structure of femoral bone from patients with severe primary osteoarthritis by comparison with age and sex matched controls. METHOD:Specimens were taken from 18 male and 18 female pairs. One of each pair was a normal control, the other having severe primary osteoarthritis...

journal_title：Osteoarthritis and cartilage

authors： Fazzalari NL,Parkinson IH

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE:To determine the within- and between-patient variability in the concentrations of synovial fluid, serum and urine markers of joint tissue metabolism in a cohort of patients with knee pain and cartilage changes consistent with early-stage knee osteoarthritis. DESIGN:Samples of synovial fluid, serum, and urine...

journal_title：Osteoarthritis and cartilage

authors： Lohmander LS,Dahlberg L,Eyre D,Lark M,Thonar EJ,Ryd L

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:To clarify the relationship between type or direction of cartilage injury and its repair process, we investigated defects produced in rat knees histologically, immunohistochemically, and histomorphometrically. METHODS:A full-thickness cartilage injury (1 mm wide and 5 mm long) was produced on the patellar gr...

journal_title：Osteoarthritis and cartilage

authors： Yoshioka M,Kubo T,Coutts RD,Hirasawa Y

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:To examine the correlation between synovial fluid cartilage markers and degree of cartilage damage determined by arthroscopic evaluation in subjects with acute knee injury. DESIGN:Chondral damage was quantified using a validated arthroscopic scoring system in 20 subjects with effusive acute knee injuries of ...

journal_title：Osteoarthritis and cartilage

authors： Bello AE,Garrett WE Jr,Wang H,Lohnes J,DeLong E,Caterson B,Kraus VB

更新日期：1997-11-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate systematically the effect of tissue load, its amplitude, time of intermittence and duration of loading on the biosynthesis and release of fibronectin by intermittently loaded mature bovine articular cartilage explants. METHODS:Cyclic compressive pressure was introduced u...

journal_title：Osteoarthritis and cartilage

authors： Steinmeyer J,Ackermann B,Raiss RX

更新日期：1997-09-01 00:00:00

abstract：:Ninety-nine mature New Zealand White (NZW) rabbits underwent unilateral anterior cruciate ligament transection (ACLT) and were divided into three groups. The contralateral non-operated knees served as controls. The first group (SA) received intra-articular injections of 0.3 ml hyaluronan (HA: MW; 8 x 10(5)) beginning ...

journal_title：Osteoarthritis and cartilage

authors： Yoshioka M,Shimizu C,Harwood FL,Coutts RD,Amiel D

更新日期：1997-07-01 00:00:00

abstract：OBJECTIVE AND DESIGN:Transection of the anterior cruciate ligament 2 weeks after ipsilateral hindlimb deafferentation leads to osteoarthritis of the knee joint within 3 weeks. We analyzed the gait of six dogs that underwent this procedure in order to identify kinematic changes that could account for this rapid joint de...

journal_title：Osteoarthritis and cartilage

authors： Vilensky JA,O'Connor BL,Brandt KD,Dunn EA,Rogers PI

更新日期：1997-05-01 00:00:00

abstract：:Five hundred patients with established, symptomatic limb joint OA have been recruited into an on-going prospective study of the natural history of the condition. Four hundred and fifteen patients (mean age 65.6 years, female to male ratio 2.05:1) were available for a full clinical and radiographic review 3 years after...

journal_title：Osteoarthritis and cartilage

authors： Dieppe PA,Cushnaghan J,Shepstone L

更新日期：1997-03-01 00:00:00

abstract：:This study sought to assess the relative levels of the mRNAs of the core proteins of the small proteoglycans (PGs) biglycan, decorin and fibromodulin in the hypertrophic phase of the early osteoarthritis (OA) that follows joint injury. Experimental OA was induced in eight dogs by transection of the anterior cruciate l...

journal_title：Osteoarthritis and cartilage

authors： Dourado GS,Adams ME,Matyas JR,Huang D

更新日期：1996-09-01 00:00:00

abstract：:Human articular cartilage cells were cultured in 1.5% agarose in Dulbecco's modified Eagle's medium (DMEM) with 10% fetal calf serum or in serum-free DMEM with 0.15% bovine serum albumin. 35S-aggrecan synthesis in serum-free DMEM was between 20% and 30% of the value observed in DMEM supplemented with 10% fetal calf se...

journal_title：Osteoarthritis and cartilage

authors： Verbruggen G,Malfait AM,Dewulf M,Broddelez C,Veys EM

更新日期：1995-12-01 00:00:00

abstract：:We performed a case-controlled study to determine whether previous gynecological surgery is associated with severe osteoarthritis (OA) of the knee, the hip or the spine, as well as mild OA of the knee. Patients who underwent surgical treatment for OA were defined as having severe OA. Patients with knee pain and radiog...

journal_title：Osteoarthritis and cartilage

authors： Inoue K,Ushiyama T,Kim Y,Shichikawa K,Nishioka J,Hukuda S

更新日期：1995-09-01 00:00:00

abstract：:The articular tissue generated on carbon fiber rods in rabbit knee joints after 75 days of intermittent active motion was compared with tissue generated on carbon fiber rods whose articular surfaces were covered with a free reversed periosteal graft. Both methods were effective in generating articular tissue; however,...

journal_title：Osteoarthritis and cartilage

authors： Curtin W,Reville W,Heapes M,Lyons J,Muckle D

更新日期：1994-12-01 00:00:00

abstract：:The extracellular matrix of articular cartilage consists mainly of type II collagen and large aggregating proteoglycan (aggrecan). During arthritis and other joint diseases, the proteoglycan (PG) level of cartilage matrix is diminished, leading to impairment of normal joint function. A new method is described for meas...

journal_title：Osteoarthritis and cartilage

authors： van der Kraan PM,de Lange J,Vitters EL,van Beuningen HM,van Osch GJ,van Lent PL,van den Berg WB

更新日期：1994-09-01 00:00:00

abstract：:Regional bone mineral density (BMD, g/cm2) of the proximal tibia including the subchondral plate was measured in vivo by dual photon absorptiometry (DPA). Twenty-one women and six men with gonarthrosis (GA) were examined. Twenty-four healthy women served as controls for the women. The precision error of the BMD measur...

journal_title：Osteoarthritis and cartilage

authors： Madsen OR,Schaadt O,Bliddal H,Egsmose C,Sylvest J

更新日期：1994-06-01 00:00:00

abstract：:This paper reviews, in a first part, methods used for the clinical assessment of osteoarthritis (OA) with special reference, in a second part, to trials of drugs claimed to be chondromodulating agents. The agents examined include glycosaminoglycan-peptide complex (GP-C, Rumalon) and glycosaminoglycan-polysulfate (GAGP...

journal_title：Osteoarthritis and cartilage

authors： Theiler R,Ghosh P,Brooks P

更新日期：1994-03-01 00:00:00

abstract：:The efficacy and the safety of intra-articular injections of sodium hyaluronate were studied in patients with osteoarthritis of the knee in a randomized multicenter double-blind study. Two hundred and nine patients received five injections of either 25 mg hyaluronate/2.5 ml (verum, N = 102) or 0.25 mg hyaluronate/2.5 ...

journal_title：Osteoarthritis and cartilage

authors： Puhl W,Bernau A,Greiling H,Köpcke W,Pförringer W,Steck KJ,Zacher J,Scharf HP

更新日期：1993-10-01 00:00:00

abstract：:The significance of activating proteins (AP-1), c-fos, c-jun and jun B relative to the AP-1 responsive metallothionein, collagenase and stromelysin gene expression in the pathophysiology of osteoarthritis (OA) was investigated. The 'early' c-fos, c-jun and jun-B mRNAs were ubiquitously expressed in normal and OA human...

journal_title：Osteoarthritis and cartilage

authors： Zafarullah M,Martel-Pelletier J,Cloutier JM,Gedamu L,Pelletier JP

更新日期：1993-07-01 00:00:00

abstract：:Our objective was to investigate the factors that control chondrocyte division, namely, (1) steric hindrance caused by the surrounding matrix, (2) growth factors and (3) cell shape. Bovine articular cartilage explants and isolated chondrocytes were cultured in medium containing [3H]-TdR to measure DNA synthesis. The e...

journal_title：Osteoarthritis and cartilage

authors： Lee DA,Bentley G,Archer CW

更新日期：1993-04-01 00:00:00